Free motion backgrounds for healing skin#

Free motion backgrounds for healing skin#

The skin is a barrier between the body and the external environment. This work builds upon existing cell-based computational studies of wound healing and could be modified to investigate different stages of wound healing, impaired healing and wound treatments. In contrast, if the size of the proliferative hub is kept below some threshold, then contact inhibition has a less significant role in wound repair. By considering contact inhibited proliferation, where small cells are unable to divide, we find that a quiescent region develops if the proliferative hub is able to grow over time, essentially limiting the number of cells that are able to divide. In this paper we explore what characteristics are sufficient for wound healing, particularly focusing on cell proliferation, since wounds are not able to repair successfully without sufficient levels of cell division. This work uses mathematical and computational modelling to investigate the effect of changing the mechanical characteristics of cells in these two key regions. Recent in vivo mouse studies have identified two key regions in wounded skin tissue: A non-proliferative leading edge that actively migrates into wounded space, and a proliferative hub in which cells have enhanced mitotic properties. Given these significant socio-economic impacts, wound healing has long been a focus of scientific research. Wound management is expensive for both individuals and the health system overall, and can reduce quality of life for patients. Wound healing of the skin is a complex process that is still not well-understood. School of Mathematics and Statistics, The University of Melbourne, Parkville, VIC, Australia.